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In addition, we discovered that the AST released by RHEA@Gel could increase the expression of peroxidase and SOD in cells, thereby scavenging intracellular ROS

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In this study, DIO mice were either allowed to feed ad libitum or were calorically restricted to induce 20% body weight loss prior to 12-week treatment with either 2.64, 10.8, or 53.4 nmol of AZD2820 per day via SC minipump infusion