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We observed that 11.8% of tirzepatide-treated rs1800437-CC carrier individuals experienced vomiting, compared with 9.4% for semaglutide-treated people carrying the same genotype, although the difference was not significant ( P = 0.12, two-sample z -test

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But, if Reddit is any indication, plenty of women do report period changes on GLP-1s, including: Changes in bleeding or PMS symptoms Cycle regularity A stop to their periods Heres a sampling of the Reddit comments youll find on the topic: I have PCOS and haven't had a period in something like 5 years