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Interestingly, it had been reported a causal role of LPS in the mechanisms of thrombus formation, demonstrating an increase in molecules with prothrombotic affection, such as von Willebrand factor, in human endothelia cells after stimulation with LPS [65]

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Despite these findings, it remains unclear whether OS is a primary factor in the development of PCOS or a secondary consequence of hyperglycemia, insulin resistance, and associated cardiovascular and necrotic complications in these women (124, 132)

Histological protocol of evaluation the stomach injuries Hematoxylin and eosin and Periodic Acid Schiff (PAS) stainings Histology revealed comprehensive damage to the stomach mucosa in the ulcer control rats