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10.1016/j.bbrep.2020.100834 94 OakleyA

*Some of the vision changes may be due to other causes (e.g., diabetic eye disease progression, rapid glycaemic control, weight loss effects) rather than directly due to semaglutide itself.

The clinical escalation protocol from the Phase 2 NEJM trial established a specific titration schedule that increases the dose every four weeks, starting low and building to a target maintenance dose