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In some peptide therapeutics, advanced charge variant analysis in biosimilars mass spectrometry approaches for heterogeneity may also be required to investigate molecular heterogeneity
In particular, patients receiving long-term parenteral nutrition are at risk due to the inclusion of manganese in trace element mixtures, which can induce neurotoxicity (395)
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Case Presentation A 71-year-old female with no prior psychiatric history presented with sudden onset of: Severe anxiety Insomnia Cognitive dysfunction Fatigue Severe neck and shoulder pain Abdominal pain New intolerance to previously well-tolerated foods Symptoms began within months of moving into a new office building , suggesting a potential environmental trigger
