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Simultaneously, PCs stimulate AMPK, which increases eNOS levels and nitric oxide production, thereby enhancing vascular endothelial performance (Cui et al., 2012)

Materials and methods Literature search and search strategy Searches were conducted in a comprehensive manner for publications of relevant peer-reviewed papers and dissertations between 1990 and 2022 in the Embase, PubMed, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform, and Weipu website (VIP) databases for all clinical studies on GLP-1 interventions in AD without language restrictions, using the Medical Subject Headings (MeSH) terms such as glucagon-like peptide 1, Alzheimers disease and cognitive function

doi: 10.1038/s41574-018-0143-9 13

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