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[15] Earlier reviews found some case reports during drug development and post-marketing surveillance
In the SURMOUNT 1 trial, tirzepatide at doses of 5 mg, 10 mg and 15 mg were evaluated against placebo, with pooled tirzepatide groups resulting in significant decreases in total cholesterol, LDL-C, VLDL-C, FFA, and triglycerides and an increase in HDL-C at week 72 of follow-up [35]
Both medications work through the same GLP-1 pathway
Clinical guidelines recommend 0.8-1.0g protein per pound of goal body weight to preserve muscle mass during rapid weight loss
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