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337,340,452 Moreover, a pivotal area of research concerns the mechanisms that precipitate gouty attacks in patients with sustained monosodium urate crystal deposits

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In this context, carriers of apolipoprotein 4 (APOE4) allele, a major risk factor for AD, present with pericyte degeneration and associated BBB breakdown [42], which has been recently associated with cognitive decline, independent of AD pathology [43]