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Key Points Semaglutide slows digestion and reduces muscle contractions in the digestive tract, which can cause constipation Mostly, constipation from semaglutide is temporary and improves as your body adjusts to the medication Staying hydrated and gradually increasing dietary fiber can help soften stools and promote regular bowel movements Aerobic exercise stimulates colon contractions and helps prevent constipation You finally get that Ozempic or Wegovy prescription and are ready to lose weight and lower your blood sugar levels