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The body typically produces sufficient L-carnitine for everyday metabolic needs, and additional amounts can be obtained through dietary sources, particularly red meat, poultry, fish, and dairy products
In the same vein, mGPAT knockout mice had reduced hepatic DAG levels and were protected from HFD-induced hepatic insulin resistance [167], and shRNA knockdown of phosphatidic acid phosphatases (PAPs, also called Lipins) similarly reduced hepatic DAG levels and improved insulin sensitivity, while the overexpression of Lipin-2 using adenovirus perturbed glucose tolerance and insulin sensitivity [168,169]
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