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This multifunctionality represents a paradigm shift, transforming hydrogels from passive spacers into active modulators of the tumor microenvironment, directly addressing the spatial, biological, and biochemical limitations that have historically constrained brachytherapy efficacy

Malonaldehyde formation and DNA fragmentation: two independent sperm decays linked to reactive oxygen species

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Thus, the Ser/Thr kinase AMPK is activated during energy depletion, when the AMP/ATP ratio increases and triggers a large number of downstream effectors by stimulating ATP-generating catabolic pathways and inhibiting anabolic pathways in order to restore the energy balance