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In contrast to the CBO report that estimated that Medicare coverage for GLP-1RAs would yield $3.4 billion in health care savings and $35.5 billion in net federal spending from 2026 to 2034 (12.5 million Medicare Part D beneficiaries, 2% uptake, and 35% adherence), 20 the present study projects substantially more considerable health care savings of $18.2 billion and net spending of $47.7 billion from 2026 to 2035 (10% uptake, 10% additional discount, and 40% adherence)

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This distinction matters for both safety and physiological fidelity: the GH release follows the bodys own pulsatile pattern rather than producing a sustained supraphysiologic level