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Contraindications Do Not Use If You Have known hypersensitivity to NAD+ or any ingredient in the formulation Have active skin infection, open wounds, or severe skin conditions on the application area Warnings and Precautions Patch test first: Apply a small amount to an inconspicuous area and wait 24 hours before full-face application Avoid contact with eyes, mucous membranes, and broken skin Sun sensitivity: Use sunscreen during daytime use as retinoid-adjacent ingredients may increase photosensitivity Discontinue use and contact your provider if persistent irritation, burning, or rash occurs Common Side Effects Temporary redness or mild stinging on application Skin dryness or flaking Mild irritation, especially during first weeks of use Use in Pregnancy and Breastfeeding Safety during pregnancy and breastfeeding has not been established

doi: 10.3390/blsf2024040007 328 NietoGRosGCastilloJ

Z., Pincay, J., Wu, Q

Notably, when compared to other white blood cells such as macrophages and lymphocytes, neutrophils exhibit the highest rate of glutamine consumption [143,144,145]