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In particular, commenters expressed concerns about the specific instruction, in the definition of the median allowed amount and the 10th and 90th percentile allowed amounts, stating that should the calculated percentile fall between two observed allowed amounts, the percentile allowed amount is the next highest observed value. These commenters indicated this deviation from the standard way of calculating a percentile when it falls between two observed values would require hospitals to implement custom formulas for these calculations rather than the out-of-the-box formulas, increasing hospital burden

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doi:10.1007/s00380-004-0822-4

For the most part, mechanistic assignments are based on interpretation of recurring identifiable absorption signals, particularly charge transfer absorption, in combination with analytical fitting, numerical integration fitting and spectral deconvolution