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Apoptosis by cisplatin requires p53 mediated p38alpha MAPK activation through ROS generation

[61] Cyanide poisoning [edit] For cyanide poisoning, a large amount of hydroxocobalamin may be given intravenously and sometimes in combination with sodium thiosulfate

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Two further classes of enzymes which contribute to superoxide production are NADPH oxidases of which several isoforms are present in RBC (George et al., 2013) and endothelial NO synthase which is present in human and mouse RBC (Kleinbongard et al., 2006) and produces O 2 when L-arginine levels are low (Mihov et al., 2009)