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4.1 Clinical relevance of the CLP model The CLP model was selected for its unique ability to recapitulate core clinical features of SAE: polymicrobial sepsis, hippocampal neurodegeneration, and chronic cognitive impairment (Yin et al., 2023)

Why the Neck Ages Faster Than the Face The neck has: Thinner dermal structure Fewer oil glands Constant movement High sun exposure Rapid collagen depletion after 35 By age 40+, collagen production can decline by up to 1% per year

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Only six of the included studies focused on autism