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However, it was dramatically attenuated in the adult subjects

In the LEADER (liraglutide) and SUSTAIN-6 (semaglutide) trials [2, 3], the GLP-1RAs rapidly and greatly decreased HbA 1c levels compared to placebo, which may have partly contributed to the increased incidence of diabetic retinopathy complications observed in SUSTAIN-6 (HR: 1.76 [95% CI 1.11, 2.78])