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Although calories and augmented alcohol metabolism are other aspects that might influence the data, these seem unlikely because the GLP-1 pathway suppresses drug responses that are independent of calories and because liraglutide does not change the blood alcohol levels (Vallof et al., 2015)

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Carefully selecting WRCs as follow-on/lead indications to gain reimbursement across markets where weight loss is unlikely to get covered, developing well thought out go-to-market strategy including direct-to-consumer and digital health models, and ensuring there is adequate manufacturing capacity to meet demand are also critical to success