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K.) and Grant-in-Aid for Scientific Research, KAKENHI [grants 25116002 (to H.K.) and 16H01300 (to S.A.K.)]

They soon realised that overproduction of ketones in the body was responsible for the coma, now known as diabetic ketoacidosis (VanItallie, Nufert)

A randomized trial assessing the effect of tirzepatide (Mounjaro/Zepbound) found that withdrawing tirzepatide led to substantial regain of lost weight in less than two years