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Following the electrophysiological testing, histology testing took place by initially collecting a 10-mm long piece of the spinal column and the surrounding muscle

Cellular experiments further confirmed that the L-OPA1/S-OPA1 ratio and Irisin/FNDC5 expression were significantly upregulated in 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR)-treated cardiomyocytes, which significantly increased PINK1/Parkin, SOD2 expression, and LC3II/I ratio, decreased p62 expression, and increased mitophagy and antioxidant capacity in AICAR-treated cardiomyocytes (Li H