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30 min) significantly inhibits 1 g/mL Doxycycline (HY-N0565)-induced caspase-3/9 activation, reduces reactive oxygen species (ROS) generation and apoptosis, and maintains glutathione levels in thioredoxin TRX2-deficient DT40 cells [1]

The quantification of metabolites was calculated by an isotope ratio-based approach according to published methods 100

PET/CT examinations PET/Computed Tomography (CT) assessment of GCGR and GLP1R availability was performed both at baseline, before start of treatment, and after around 3 weeks of treatment on Day 17 (GLP1R) and Day 20 (GCGR)