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genetic associations with other risk factors were obtained from summary statistics in the Neale Lab GWAS of the UK Biobank, controlling for age, age 2 , and 20 principal components (Additional file 1: Table S1)

A longitudinal study published in Diabetologia (2019) followed over 900 non-diabetic individuals and found that higher circulating palmitoleic acid levels were independently associated with better insulin sensitivity, improved beta-cell function, and better glucose toleranceeven after adjusting for age, sex, and body fat

Its effects include improved cerebral blood flow, antioxidant activity, and modulation of neurotransmitter systems

Together they address both input and metabolism