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Furthermore, catalpol mitigates Cisplatin-induced kidney injury and suppresses the inflammatory response, including reductions in Tumor Necrosis Factor-alpha (TNF-), interleukin-6 (IL-6), IL-1, IL-8, and iNOS, by activating Nrf2 and inhibiting the NF-B signaling pathway (Zhang J

Challenges and perspectives of targeting the Trx system in neurodegenerative diseases Synergistic and antagonistic interactions in complex disease networks The Trx system interacts dynamically with multiple signaling pathways related to oxidative stress, inflammation, apoptosis and cell survival

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