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They don't compete for the same receptors

Zhang S, Chuah SJ, Lai RC, Hui JHP, Lim SK, Toh WS

Two peptides with complementary mechanisms in a single formulation

Estrogen Metabolism Support Optimizing hepatic Phase I and Phase II estrogen detoxification reduces the burden of potentially carcinogenic estrogen metabolites (particularly 4-OH and 16-OH estrone) and may reduce estrogen-driven fibroid growth: DIM (diindolylmethane): Shifts estrogen metabolism toward the favourable 2-OH pathway Calcium-D-glucarate: Inhibits -glucuronidase, preventing deconjugation and reabsorption of estrogens in the gut (Note: off-the-shelf detox kits from health food stores are not equivalent to therapeutic doses of these specific compounds) N-acetylcysteine (NAC): Supports glutathione synthesis and Phase II sulphation 3