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It presents this as a provider judgment made alongside kidney function, gastrointestinal history, and thyroid status rather than a general ranking of the two drugs

39 GLP-1RAs and Coronary Artery Disease Epicardial CAD is commonly seen in HFpEF

Previous research has demonstrated increased amino acid catabolism in skeletal muscle with low glycogen content, and further research is needed to determine if skeletal muscle loss in patients taking GLP-1RA can be mitigated through synergistic pharmaceutical or dietary interventions to maximize skeletal muscle glycogen content [165]

The ADAs 2026 update discusses GLP-1 RA effects on eye health including potential impacts on diabetic retinopathy progression, glaucoma, and macular degeneration