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A difference with a two-tailed P value less than 0.05 was considered statistically significant

b d , Current binding modes of GPCR allosteric modulators

Cells from KK-Ay mice exposed to 1 mM glucose were strongly depolarized compared with those from KK mice (approximately 30 mV), and there was no further depolarization by increasing glucose to 10 mM with no clear action potential firing (Figure 5, D and E)

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