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Curcumin-encapsulated hydrogels have demonstrated efficacy in promoting wound healing, mitigating inflammation, and facilitating tissue regeneration (Kamar et al., 2019), conducted a study revealing that a hydrogel infused with curcumin markedly expedited wound repair in a diabetic rat model

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Two carboxyl groups on a side chain disclosed by patent CN111378028A are naked and are not protected by a protective group, the purity of an intermediate obtained in the subsequent coupling reaction with an Arg34GLP-1 (9-37) main peptide chain is not high, only 67.5 percent is obtained, the yield is seriously reduced, and the pH value in the reaction has a large influence on the side chain modification, so that various byproducts which are difficult to remove are easily generated, such as a double-modified impurity byproduct with both the 26 th position and the end position of the main peptide chain modified and a byproduct with the end position of the main peptide chain modified

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