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1.4 Indications Approved by Regulatory Authorities Sematrinity is primarily indicated for: Type 2 diabetes mellitus management Adjunct therapy to diet and exercise Reduction of cardiovascular risk in select populations 1.5 Growing Role in Metabolic Disease Management With the escalating prevalence of metabolic syndrome, semaglutide-based therapies have become integral

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6 Results from a systematic review and meta-analysis study showed that following discontinuation of weight management medications: Patients are estimated to return to baseline weight within 1.7 years 1,** Results from that same study also highlighted that following discontinuation of weight management medications: Cardiometabolic benefits may be lost, with markers estimated to return to baseline within 1.4 years 1,** Ongoing obesity treatment is needed for maintaining weight loss and improvements in cardiometabolic markers 4 Addressing Discontinuation Starts With Understanding What May Influence Adherence and Persistence 5 Long-term adherence is shaped by multiple, interconnected factorsand ongoing research continues to explore how challenges may interact over time

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