Based on a 2005 case report published in the International Archives of Allergy and Immunology , we advise people with allergies to artichoke to steer clear of Wing Man, as the associated inulin content may cause severe anaphylactic shock.39 Also, because of said inulin, people with FODMAP sensitivities (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) would do well to avoid Wing Man to prevent consequent gastrointestinal symptoms, such as bloating, belching, diarrhea, abdominal pain, and nausea.63 Even people without such intolerances may experience side effects such as a temporary increase in flatulence and a significant increase in mild-to-moderate bloating, similar to those with FODMAP sensitivities.40 41 Wing Man has a couple of other qualities to recommend it as a milk thistle supplement
Andrew: Oh, thank you
The Phase 2 NEJM trial mapped this relationship across four dose tiers, and the Phase 3 TRIUMPH-4 data confirmed it at scale (Jastreboff et al., NEJM, 2023)
First, patients with Wilson disease or other copper metabolism disorders should avoid systemic GHK-Cu entirely
