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Loss-of-function mutations affecting genes in the leptin-melanocortin pathway, particularly MC4R , POMC , PCSK1 and LEPR, (Figure 2), predispose individuals to hyperphagia and severe early onset obesity 28 (Table 3)

Coyle L, Entezaralmahdi M, Adeola M, Mobolaji, M, et al

p53 is involved in the regulation of more than 500 target genes and thereby controls a broad range of cellular processes, including metabolic adaptation, DNA repair, cell cycle arrest, apoptosis, and senescence Because of its pro-apoptotic function, p53 is recognized as tumour suppressor, and is found mutated in more than half of all human cancers affecting a wide variety of tissues

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