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In a 52-week prospective study (n=194, T2DM), GLP-1RA therapy produced significant reductions in HbA1c (0.69%), HOMA-IR (1.23), fat mass (4.7 kg), and visceral adipose tissue (0.72 L) at 12 months, with skeletal muscle mass preserved

Ng and colleagues synthesized them, added a tyrosine at the start for better stability, and obtained AOD-9604 , Anti-Obesity Drug 9604, the code name of the development program