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This is the most commonly used approach, and its strategy is to modify the second N-terminal amino acid position (Ala8) to protect from degradation by DPP-4
Acta Neurobiol Exp 79(2):113
Thats why therapies like CJC-1295 focus on restoring the natural signals rather than replacing the hormone outright
PMCID: PMC6678539 Bicknell LS, Farrington-Rock C, Shafeghati Y, Rump P, Alanay Y, Alembik Y, Al-Madani N, Firth H, Karimi-Nejad MH, Kim CA, Leask K, Maisenbacher M, Moran E, Pappas JG, Prontera P, de Ravel T, Fryns JP, Sweeney E, Fryer A, Unger S, Wilson LC, Lachman RS, Rimoin DL, Cohn DH, Krakow D, Robertson SP
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