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As the medication remains investigational, its eventual place alongside existing GLP-1 therapies will depend on the completion of its clinical programme

As Case 2 demonstrated, a patient may tolerate one drug in the class (semaglutide) but not another (tirzepatide), suggesting the reaction may be specific to certain agents or their unique pharmacologies

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However, chronic stimulation of these paracrine myofibroblast pathways in IBD raises theoretical safety concerns regarding stricturing, fibrosis risk, and the necessity for rigorous dysplasia surveillance, which remain critical hurdles for long-term clinical development