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ACSL4 is commonly upregulated in OA cartilage and synovial cells, expediting the activation and incorporation of PUFAs into membrane phospholipids and consequently heightening ferroptotic sensitivity (57, 74)

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Stephanie Weiss, M.D., Ph.D., assistant director for the Clinical Research, Medication Development Program at NIDA, shared data from the first published clinical trial of GLP-1 RAs in alcohol use disorder: in patients with obesity with a BMI over 30, exenatide reduced heavy drinking days by 23.6% and lowered total alcohol intake