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In animal reproduction studies, there was no evidence of adverse developmental effects when pregnant rats and rabbits were treated orally with amlodipine maleate during organogenesis at doses approximately 10 and 20-times the maximum recommended human dose (MRHD), respectively
Others who worked on GLP-1 have gotten awards, but I felt that when it became a drug, that was my award
A rule of thumb is to cut the dosage in half when dealing with an intermediate metabolizer or a mild-moderate drug interaction, but dosing is difficult and unpredictable with poor or ultra-rapid metabolizers
Paonessa is a highly skilled colorectal surgeon who specializes in treating hemorrhoids, using conservative approaches where possible
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