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Carnitine also has an anti-inflammatory effect as the integration of diet with LC decreases the anti-proliferative effect induced by the presence of interleukins such as TNF- and its detrimental action reducing the consumption of glucose of the embryo in its early development [98] and reducing growth of the inner cell mass and trophoectoderm in the blastocyst, which leads to delayed embryonic development and reduction of vitality of the embryo [99, 100]

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Liver-specific IGF-I gene deficient mice exhibit accelerated diabetes in response to streptozotocin, associated with early onset of insulin resistance