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While the IOM had based B12 needs on the amount required to correct hematological parameters for people with pernicious anemia, the EFSA had almost 20 more years of research to draw on, and concluded that the most suitable approach was basing needs on biomarkers (serum B12, holotranscobalamin, MMA, and homocysteine)

(PubMed)

Researchers commonly evaluate: Batch-specific Certificates of Analysis (COAs) High-performance liquid chromatography (HPLC) purity testing Identity verification Independent analytical testing Manufacturing documentation Batch traceability These quality-control measures help support transparency and provide researchers with additional information regarding the identity and composition of a research material

Severe B12 deficiency is widely reported and leads to pernicious anemia since your body needs B12 to make red blood cells, and a deficiency limits its capabilities to build them