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It becomes effective only when these two conditions are met: You are in a calorie deficit (eating fewer calories than you burn) You are doing regular exercise ideally cardio or strength training Think of it like this: L-carnitine is the spark plug but you still need the engine (exercise) and the fuel (proper diet) to make the car move
Two 10-year case-control studies over very large samples of people with diabetes ( N = 360,205 and N = 73,869, respectively) equally observed no association between GLP-1RA use and incident depression 202,203
Some researchers have even reported cases of severe thiamine (vitamin B1) deficiency leading to Wernicke encephalopathy, a potentially dangerous neurological condition
Saudi J Gastroenterol
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