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In addition, inhibiting METTL17 significantly reduces mitochondrial RNA methylation, impairing the translation of mitochondrial protein-coding genes, affecting mitochondrial energy metabolism, and enhancing mitochondrial and intracellular ROS and lipid peroxidation levels

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The antipsychotic activity of phenothiazines may be related to any or all of these effects, but it has been suggested that the drugs' effects on dopamine are probably most important

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