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Why three is more than one plus one plus one The combination isn't just additiveit may be synergistic: GLP-1 and GIP together enhance appetite suppression more than either alone Glucagon increases metabolic rate and fat burning The combined effect on energy balance exceeds what any single mechanism achieves Different pathways may reduce the body's ability to adapt and plateau This helps explain why Phase 2 trials showed weight loss exceeding 24%greater than approved single or dual agonists
Tanaka K, Sasayama T, Irino Y, Takata K, Nagashima H, Satoh N, Kyotani K, Mizowaki T, Imahori T, Ejima Y, Masui K, Gini B, Yang H, Hosoda K, Sasaki R, Mischel PS, Kohmura E (2015) Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment
Risk ratios (RR) for the renal outcome estimates according to direct (DPP-4 inhibitors, GLP-1RA and SGLT-2 inhibitors against placebo) and indirect (DPP-4 inhibitors vs GLP-1RA or SGLT-2 inhibitors, and GLP-1RA vs SGLT-2 inhibitors) comparisons
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