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10.1074/jbc.M111.262519 J

Tirzepatide should be injected subcutaneously into the abdomen, thigh, or upper arm (with upper arm injections typically administered by a caregiver), and patients should avoid using the same site for consecutive injections

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Over-the-counter products marketed as a lip dark spot remover may slightly lighten surface discoloration, but they rarely eliminate true sun spots, freckles, or smoking-related pigmentation