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as are certain blood disorders like sickle cell anemia, beta-thalassemia, and other causes of hemolytic anemia (Shaffer 2018

NF-KB is sensitive to ROS, and it modulates the transcription of genes encoding endothelin-1, tissue factor, and thrombomodulin (198)

Current strategies focus not only on targeting the BBB endothelium but also on the effective transport of specific compounds across it and the subsequent targeted drug release at appropriate targets in the brain (32)

This problem refers especially to environmental samples and could be solved by proper sample preparation, such as application of sample filtration (glass filers, syringe filters) and extraction (Ramirez et al