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Further relevant references were identified by backward and forward citation searching

doi: 10.1186/s13229-021-00447-5 151 Zuiderwijk-SickE

"The growth hormone/IGF-1 axis is an attractive target for preserving muscle mass in cirrhosis, but the liver's dual role as both a GH effector organ and a metabolic clearance site means that any GH-axis intervention must account for the degree of hepatocellular dysfunction," according to the Endocrine Society's position statement on GH in chronic illness (Endocrine Society Clinical Practice Guideline, 2011)