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Employers who provide insurance to their employees work with pharmacy benefit managers to manage prescription drug benefits, and in doing so they put in place a dizzying array of limitations to try to control costs

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Because, in excitatory neurons, spines are considered as the morphological substrate for restricting the spread of synaptically induced [Ca 2+ ] i rises, thus restricting plasticity to the activated synapses, it was proposed that, in aspiny dendrites, input-specificity of plastic changes might be compromised