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GLP-1 receptors are found in the hypothalamus (appetite regulation), hippocampus (memory formation), brainstem (nausea responses), ventral tegmental area and nucleus accumbens (reward circuits), amygdala (emotional processing), prefrontal cortex (executive function), and substantia nigra (motor control)

Compared to the control group, levels of several amine metabolites (methionine, homocysteine, threonine, proline, alanine, cystathionine, valine, and glycylglycine) were significantly reduced in CIA mice, which may be related to muscle atrophy ( Other metabolites may also mediate the secretion of inflammatory cytokines and are involved in the inflammatory pathway of RA

SURPASS-3, tirzepatide versus degludec