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evidence mixed) Example discussed online: semaglutide + AOD-9604 Mechanistic logic: GLP-1-based meds drive appetite reduction, improved glycemic regulation, and downstream weight loss

Diabetes Obes Metab 9:869878 Ahren B, Foley JE, Ferrannini E et al (2010) Changes in prandial glucagon levels after a 2-year treatment with vildagliptin or glimepiride in patients with type 2 diabetes inadequately controlled with metformin monotherapy

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demonstrated that IL-6 deficiency attenuated the development of SIM through upregulation of the peroxisome proliferator-activated coactivator-1 and inhibition of mitochondrial ROS production (16)