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In an AD mouse model, liraglutide reduces the activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome in the microglia, leading to the decreased production of proinflammatory cytokines and A plaques [52]

In response to the Icelandic Medicines Agencys alert regarding reports of suicidal thoughts and self-injury linked to the use of liraglutide and semaglutide, we undertook a comprehensive analysis to assess the risk of suicide/self-injury associated with various GLP-1RAs