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Copper-Dependent Enzyme Activation Studies indicate that GHK-Cu provides copper for the activation of copper-dependent enzymes including lysyl oxidase (critical for collagen and elastin cross-linking), superoxide dismutase (SOD, an antioxidant enzyme), and tyrosinase

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Physical dependence is a state that develops as a result of a physiological adaptation in response to repeated drug use, manifested by withdrawal signs and symptoms after abrupt discontinuation or a significant dose reduction of a drug