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I think we have proof of concept here that genetics is playing a role in terms of GLP-1 efficacy and side effects, said Adam Auton, a vice president at the 23andMe Research Institute and the senior author on the paper, which was published in Nature on Wednesday

These occur in a significant proportion of patients, particularly during the initial weeks of treatment or following dose increases

Even so, having a more typical MC1R genotype suggests this receptor is less likely to be a major limiting factor within the broader melanocortin network