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In this trial, GLP-1 RA showed CV benefits on blood pressure, vascular endothelium, atherosclerosis progression and inflammation, and myocardial ischemia [52]

& Piemonte, F

Cel Neurosci 72, 4653

The overwhelming dominance of ROS generated by enzymes like NADPH oxidases and xanthine oxidase over antioxidants like superoxide dismutase causes cell injury and tissue damage through direct injury, lipid peroxidation and protein oxidation leading to protease release and antioxidant and antiprotease enzyme inactivation as well as alteration of transcription factors activator protein-1 and NFB